EBMcalc Medical Calculator

Phenytoin Total Drug Level (Adjusted for Hypoalbuminemia and Renal Function)

The EBMcalc module Phenytoin Total Drug Level (Adjusted for Hypoalbuminemia and Renal Function) is available in EBMcalc Complete Edition.

This calculator yields the following results:

Phenytoin Adjusted

Equation parameters include:

Phenytoin Measured
Renal Fx
Albumin

References

Martin E, Tozer TN, Sheiner LB, Riegelman S. The clinical pharmacokinetics of phenytoin. J Pharmacokinet Biopharm. 1977 Dec;5(6):579-96. PubMed ID: 599408
Dasgupta A, Dennen DA, Dean R, McLawhon RW. Prediction of free phenytoin levels based on [total phenytoin]/[albumin] ratios. Potential errors with hypoalbuminemia. Am J Clin Pathol. 1991 Feb;95(2):253-6. PubMed ID: 1992618
Kiang TK, Ensom MH. A Comprehensive Review on the Predictive Performance of the Sheiner-Tozer and Derivative Equations for the Correction of Phenytoin Concentrations. Ann Pharmacother. 2016 Apr;50(4):311-25. PubMed ID: 26825643

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