EBMcalc Medical Calculator

COVID-19 and the Systemic Immune-Inflammation Index (SII)

Input

Absolute Neutrophil Count

Platelets

Absolute Lymphocyte Count

Result

Important: Inputs must be complete to perform calculation.

SII

Decimal Precision

SII Interpretation

<=618.8:

Lower criticality risk

>618.8:

Higher criticality risk

Data action

Include literature references: Yes No

Notes

This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
The SII should be calculated from blood counts at the time of hospital admission.
For this calculation, note that the platelet count unit of measure is different from the white blood cell count units of measure.
Subjects with an SII >618.8 had a 4.7 times higher mortality. This cut-off had sensitivity of 80% and specificity of 61.5%.^[1]

Equations used

SII = AbsoluteNeutrophilCount * Platelets / AbsoluteLymphocyteCount

References

Karaaslan T, Karaaslan E. Predictive Value of Systemic Immune-inflammation Index in Determining Mortality in COVID-19 Patients. J Crit Care Med (Targu Mures). 2022 Aug 12;8(3):156-164. PubMed ID: 36062039

Associated Logical Observation Identifiers Names and Codes [LOINC]

Parameter	LOINC's and Suggested Units
Absolute Neutrophil Count	751-8 : 10^3/microL 26499-4 : 10^3/microL 753-4 : 10^3/microL
Platelets	777-3 : x10^9/L 26515-7 : x10(3)/mcL
Absolute Lymphocyte Count	731-0 : x10^3/microL 26474-7 : x10^3/microL 732-8 : x10^3/microL

This material contains content from LOINC (http://loinc.org). LOINC is copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license. LOINC® is a registered United States trademark of Regenstrief Institute, Inc.

Associated HCC ICD10-CM codes

B97.29

Other coronavirus as the cause of diseases classified elsewhere

D68.69

Other Thrombophilia (COVID-19 associated hypercoagulability)

D68.8

Other Specified Coagulation Defects (COVID-19 associated coagulopathy)

J12.82

Pneumonia due to coronavirus disease

M35.81

Multisystem inflammatory syndrome.

M35.89

Other specified systemic involvement of connective tissue

U07.1

COVID-19

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