EBMcalc Medical Calculator

COVID-19 and the Prognostic Nutrition Index (PNI)

Input

Albumin

Absolute Lymphocyte Count

Result

Important: Inputs must be complete to perform calculation.

PNI

Decimal Precision

PNI Interpretation

PNI <43.7:

In-hospital mortality odds ratio 12.2

PNI >=43.7 and <=51.4:

In-hospital mortality odds ratio 1.5

PNI >51.4:

In-hospital mortality odds ratio 1 (index)

Data action

Include literature references: Yes No

Notes

In this calculator, mcg is the abbreviation for micrograms.
This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
In-hospital mortality odds ratios were adjusted for covariates.^[2]
PNI cutoffs predicting in-hospital mortality rage from 36.85 (sensitivity 70.29%, specificity 69.23%)^[3] to 42.1 (sensitivity 81.8%, specificity 72%).^[2]

Equations used

PNI = (10 * Albumin) + (0.005 * AbsoluteLymphocyteCount)

References

Onodera T, Goseki N, Kosaki G. Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai Zasshi. 1984 Sep;85(9):1001-5. Japanese. PubMed ID: 6438478
Cınar T, Hayıroglu Mİ, Cicek V, et al. Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? Heart Lung. 2021 Mar-Apr;50(2):307-312. PubMed ID: 33482433
Rashedi S, Keykhaei M, Pazoki M, et al. Clinical significance of prognostic nutrition index in hospitalized patients with COVID-19: Results from single-center experience with systematic review and meta-analysis. Nutr Clin Pract. 2021 Jul 16. PubMed ID: 34270114

Associated Medical Subject Headings [MeSH]

COVID-19, Cardiovascular Diseases, Cross-Sectional Studies, Digestive System Neoplasms, Heart Disease Risk Factors, Hospital Mortality, Humans, Nutrition Assessment, Nutritional Physiological Phenomena, Nutritional Status, Parenteral Nutrition, Prognosis, Retrospective Studies, Risk, Risk Factors, SARS-CoV-2, Total

Associated Logical Observation Identifiers Names and Codes [LOINC]

Parameter	LOINC's and Suggested Units
Albumin	1751-7 : g/dL
Absolute Lymphocyte Count	731-0 : x10^3/microL 26474-7 : x10^3/microL 732-8 : x10^3/microL

This material contains content from LOINC (http://loinc.org). LOINC is copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license. LOINC® is a registered United States trademark of Regenstrief Institute, Inc.

Associated HCC ICD10-CM codes

B97.29

Other coronavirus as the cause of diseases classified elsewhere

D68.69

Other Thrombophilia (COVID-19 associated hypercoagulability)

D68.8

Other Specified Coagulation Defects (COVID-19 associated coagulopathy)

J12.82

Pneumonia due to coronavirus disease

M35.81

Multisystem inflammatory syndrome.

M35.89

Other specified systemic involvement of connective tissue

U07.1

COVID-19

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